N4 - Neuroscience in the Clinic: Immunotherapies in Neurological Disease

Event Time: Wednesday May 8, 2019 1:00 pm to 3:00 pm
Topic(s): Autoimmune Neurology, Neuromuscular and Clinical Neurophysiology (EMG)
Director(s): John Corboy MD, FAAN, Holly Hinson MD, MCR, FAAN
Description: Over the last 30 years, the use of immunotherapies for Neurological disease has greatly expanded and become more specific for distinct targets. This program will use neuromyelitis optica spectrum disorder (NMOSD) as a disease paradigm to investigate the role of immunotherapies in neurologic illness. NMOSD is characterized by recurrent attacks of optic neuritis and longitudinally extensive transverse myelitis, caused by antibodies to aquaporin-4. Attack prevention with immunosuppressive drugs is currently considered the standard of care, with interleukin-6 receptor inhibitor (SA-237), eculizumab and an anti-CD19 antibody (inebilizumab) emerging as potential therapies. This program will cover mechanism of action of the immunotherpies in question, risk management in special situations like pregnancy and vaccination, animal models, and the role of basic science as a route to novel therapies applied in the clinic.
Completion Message: Participants should become familiar with the emerging role of immunotherpy in neurologic illness, including the practical application to NMOSD, and get an update on new break-throughs in the field with their basic science underpinnings.
CME Credits: 2
Core Competencies: Patient Care, Medical Knowledge, Practice-Based Learning and Improvement

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