N4 - Neuroscience in the Clinic: Immunotherapies in Neurological Disease
| Event Time: | Wednesday May 8, 2019 1:00 pm to 3:00 pm |
| Topic(s): | Autoimmune Neurology, Neuromuscular and Clinical Neurophysiology (EMG) |
| Director(s): | John Corboy MD, FAAN, Holly Hinson MD, MCR, FAAN |
| Description: | Over the last 30 years, the use of immunotherapies for Neurological disease has greatly expanded and become more specific for distinct targets. This program will use neuromyelitis optica spectrum disorder (NMOSD) as a disease paradigm to investigate the role of immunotherapies in neurologic illness. NMOSD is characterized by recurrent attacks of optic neuritis and longitudinally extensive transverse myelitis, caused by antibodies to aquaporin-4. Attack prevention with immunosuppressive drugs is currently considered the standard of care, with interleukin-6 receptor inhibitor (SA-237), eculizumab and an anti-CD19 antibody (inebilizumab) emerging as potential therapies. This program will cover mechanism of action of the immunotherpies in question, risk management in special situations like pregnancy and vaccination, animal models, and the role of basic science as a route to novel therapies applied in the clinic. |
| Completion Message: | Participants should become familiar with the emerging role of immunotherpy in neurologic illness, including the practical application to NMOSD, and get an update on new break-throughs in the field with their basic science underpinnings. |
| CME Credits: | 2 |
| Core Competencies: | Patient Care, Medical Knowledge, Practice-Based Learning and Improvement |
| Start/End Time | Title | Faculty |
|---|---|---|
| 1:00 PM - 1:10 PM | Case Presentation | Stacey Clardy MD, PhD |
| 1:10 PM - 1:30 PM | Neuroscience Background | Jeffrey L. Bennett MD, PhD, FAAN |
| 1:30 PM - 1:40 PM | Clinical Follow up | Stacey Clardy MD, PhD |
| 1:40 PM - 2:00 PM | Summary of the Science and Future Directions | John Corboy MD, FAAN |
| 2:30 PM - 3:00 PM | Panel Discussion | Faculty |
| Speaker | Disclosure |
|---|---|
| Jeffrey L. Bennett, MD, PhD, FAAN | Dr. Bennett has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with MedImmune, Equillium, Chugai, Frequency Therapeutics, Clene Neuroscience. Dr. Bennett has received research support from Mallinckrodt, EMD Serono. |
| Stacey Clardy, MD, PhD | Dr. Clardy has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Adivo Associates (<$1000, to University Development account). Dr. Clardy has received personal compensation in an editorial capacity for Neurology Podcast Section Editor. |
| John Corboy, MD, FAAN | Dr. Corboy has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Prime CME, Mylan, Novartis. Dr. Corboy has received personal compensation in an editorial capacity for Editor, Neurology: Clinical Practice. Dr. Corboy has received research support from Med Day, Novartis. |
| Start Time | Pub. | Title | Presenter |
|---|---|---|---|
| 1:00 PM | 001 | Pharmacokinetics, Pharmacodynamics, and Exposure-response Analyses of Ocrelizumab in Patients With Multiple Sclerosis |
Disclosure: Dr. Kletzl has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Hoffmann-La Roche. Dr. Kletzl holds stock and/or stock options in Hoffmann-La Roche which sponsored research in which Dr. Kletzl was involved as an investigator. Dr. Kletzl holds stock and/or stock options in Hoffmann-La Roche. Dr. Kletzl has received research support from Hoffmann-La Roche.
|
| 1:00 PM | 002 | Subcutaneous Immunoglobulin in Myasthenia Gravis: Results of a North American Open Label Study |
Disclosure: Dr. Dimachkie has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Alnylam, Audentes, Biomarin, Catalyst, CSL-Behring, Genzyme, Mallinckrodt, Momenta, Novartis, NuFactor, Octapharma, RMS Medical, Sanofi, Shire and Terumo. Dr. Dimachkie has received research support from Alexion, Alnylam, Amicus, Biomarin, Bristol-Myers Squibb, Catalyst, CSL-Behring, FDA/OPD, GlaxoSmithKline, Genentech, Grifols, MDA, NIH, Novartis, Genzyme, Octapharma, UCB Biopharma, Viromed and TMA.
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