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PL4 - Clinical Trials Plenary Session

Event Time: Tuesday April 25, 2017 9:15 am to 11:30 am
Topic(s): Aging, Dementia, Cognitive, and Behavioral Neurology, Cerebrovascular Disease and Interventional Neurology, Child Neurology and Developmental Neurology, Epilepsy/Clinical Neurophysiology (EEG), Headache, MS and CNS Inflammatory Disease, Neuromuscular and Clinical Neurophysiology (EMG)
Description: This session covers important clinical topics identified from other society meetings that affect patient care. The latest updates within several clinical trials conducted over the course of the last year will be presented.
Completion Message:
CME Credits: 2.25
Core Competencies:

Program Speakers - Tentative

Start/End Time Title Faculty
9:15 AM - 9:30 AM Effect of Intensive Systolic Blood Pressure Lowering on Hematoma Expansion in Patients with Intracerebral Hemorrhage: Analysis of Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II Trial Joshua Goldstein  
9:30 AM - 9:45 AM Longitudinal Effect of Eteplirsen Versus Historical Control on Ambulation in Duchenne Muscular Dystrophy Jerry Mendell MD, FAAN 
9:45 AM - 10:00 AM Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine Scott Powers PhD 
10:00 AM - 10:15 AM Efficacy of Siponimod in Secondary Progressive Multiple Sclerosis: Results of the Phase 3 Study Ludwig Kappos MD, FAAN 
10:15 AM - 10:30 AM A 2-year Multidomain Intervention of Diet, Exercise, Cognitive Training, and Vascular Risk Monitoring Versus Control to Prevent Cognitive Decline in At-risk Elderly People (FINGER): A Randomized Controlled Trial Miia Kivipelto MD 
10:30 AM - 10:45 AM AVXS-101 Phase 1 Gene Therapy Clinical Trial in SMA Type 1: Event Free Survival and Achievement of Developmental Milestones Jerry Mendell MD, FAAN 
10:45 AM - 11:00 AM Cannabidiol (CBD) Reduces Convulsive Seizure Frequency in Dravet Syndrome: Results of a Multi-Center, Randomized, Controlled Trial (GWPCARE1) J. Helen Cross  
11:00 AM - 11:15 AM MGTX: Results of the Multinational Thymectomy Trial in Non-thymomatous Myasthenia Gravis Gil Wolfe MD, FAAN 
11:15 AM - 11:30 AM Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Migraine Prevention: Primary Results of the STRIVE Trial Peter Goadsby MD, PhD 


Speaker Disclosure
J. Helen Cross Patent applications are submitted for a C10 preparation Betasht, with UCL/Royal Holloway and Vitaflo. Research support from Vitaflo – clinical trial Betashot in epilepsy Chief Investigator UK GW Pharma Study and local PI, CBD in DRavt syndrome and Lennox Gastaut Syndrome PI Fenfluramine in Dravet syndrome All remuneration to the department Vitaflo – clinical trial Betashot in.

Peter Goadsby, MD, PhD Dr. Goadsby has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Alder Biopharmaceuticals, Allergan, Amgen, Electrocore, Eli-Lilly, eNeura, Novartis, Teva. Dr. Goadsby has received personal compensation in an editorial capacity for Journal Watch, Up-to-Date, Oxford Univeristy Press, Massachusetts Medical Society, Walters Kluwer. Dr. Goadsby has received compensation for serving on the Board of Directors of Trigemina Inc. Dr. Goadsby has received research support from Amgen.

Joshua Goldstein Dr. Goldstein has received research funding from Pfizer, Boehringer Ingelheim, and Portola.

Ludwig Kappos, MD, FAAN All payments have been transferred to a research account of the University Hospital Basel -> NO Personal compensation. To institution (University Hospital Basel) license fees for Neurostatus products and grants from Bayer, Biogen, Merck, Novartis, Roche, Teva, Roche Research Foundation, Swiss MS Society, and Swiss National Research Foundation.

Miia Kivipelto, MD Dr. Kivipelto has received personal compensation for activities with Pfizer as a speaker.

Jerry R. Mendell, MD, FAAN Dr. Mendell has received personal compensation for activities with AveXis, Inc. and Sarepta Therapeutics as a consultant. Dr. Mendell has received research support from Sarepta Therapeutics Inc. and AveXis, Inc.

Scott Powers, PhD Dr. Powers has nothing to disclose.

Gil I. Wolfe, MD, FAAN Dr. Wolfe has received personal compensation for activities with Grifols, Baxter, Syntimmune, and ArgenX. Dr. Wolfe has received research support from Nufactor.

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