C11 - Neuromyelitis Optica Spectrum Disorders

Event Time: Saturday April 22, 2017 10:30 am to 12:30 pm
Topic(s): MS and CNS Inflammatory Disease
Director(s): Dean Wingerchuk MD, FAAN
Description: Neuromyelitis optica spectrum disorders (NMOSD) are a collection of clinical syndromes and neuroradiological accompaniments unified by their association with an autoantibody specific for the astrocytic water channel aquaporin-4 (AQP4). Recently revised diagnostic criteria for NMOSD, which include the classic transverse myelitis and optic neuritis attacks but also define additional brain, diencephalic, and brain stem syndromes, stratify the diagnosis based on whether AQP-IgG is detected or not. Faculty will present a state-of-the-art review of NMOSD pathogenesis, diagnosis, AQP4-IgG assay interpretation, and the role of emerging autoantibodies associated with NMOSD clinical phenotypes (such as MOG-IgG) and summarize a practical approach to treatment and prevention of attacks. Case presentations will be used to illustrate key learning points during lectures and in a case-based discussion session.
Completion Message: Participants should be able to understand the clinical, neuroimaging, laboratory, and pathologic characteristics of NMOSD; compare the utility of AQP4-IgG assay methods; recognize clinical characteristics associated with MOG-IgG; be able to discuss elements of the newly revised NMOSD diagnostic criteria; and describe approaches to prevention and treatment of acute NMOSD attacks.
CME Credits: 2
Core Competencies: Medical Knowledge, Patient Care

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