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C11 - Neuromyelitis Optica Spectrum Disorders

Event Time: Saturday April 22, 2017 10:30 am to 12:30 pm
Topic(s): MS and CNS Inflammatory Disease
Director(s): Dean Wingerchuk MD, FAAN
Description: Neuromyelitis optica spectrum disorders (NMOSD) are a collection of clinical syndromes and neuroradiological accompaniments unified by their association with an autoantibody specific for the astrocytic water channel aquaporin-4 (AQP4). Recently revised diagnostic criteria for NMOSD, which include the classic transverse myelitis and optic neuritis attacks but also define additional brain, diencephalic, and brain stem syndromes, stratify the diagnosis based on whether AQP-IgG is detected or not. Faculty will present a state-of-the-art review of NMOSD pathogenesis, diagnosis, AQP4-IgG assay interpretation, and the role of emerging autoantibodies associated with NMOSD clinical phenotypes (such as MOG-IgG) and summarize a practical approach to treatment and prevention of attacks. Case presentations will be used to illustrate key learning points during lectures and in a case-based discussion session.
Completion Message: Participants should be able to understand the clinical, neuroimaging, laboratory, and pathologic characteristics of NMOSD; compare the utility of AQP4-IgG assay methods; recognize clinical characteristics associated with MOG-IgG; be able to discuss elements of the newly revised NMOSD diagnostic criteria; and describe approaches to prevention and treatment of acute NMOSD attacks.
CME Credits: 2
Core Competencies: Medical Knowledge, Patient Care

Program Speakers - Tentative

Start/End Time Title Faculty
10:30 AM - 11:15 AM NMOSD: Pathogenesis and Clinical Diagnosis Brian Weinshenker MD, FAAN 
11:15 AM - 12:00 PM NMOSD: Current and Emerging Therapies and Strategies Dean Wingerchuk MD, FAAN 
12:00 PM - 12:30 PM Case-based Discussion Faculty 

Disclosures

Speaker Disclosure
Brian G. Weinshenker, MD, FAAN Dr. Weinshenker has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Novartis, Alexion, MedImmune, Caladrius Biosciences, Brainstorm Therapeutics. Dr. Weinshenker has received royalty, license fees, or contractual rights payments from RSR Ltd, Oxford University, Hospices Civil de Lyon, MVZ Labor PD Dr. Volkmann und Kollegen GbR.

Dean M. Wingerchuk, MD, FAAN Dr. Wingerchuk has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Caladrius and MedImmune. Dr. Wingerchuk has received personal compensation in an editorial capacity for The Neurologist.. Dr. Wingerchuk has received research support from Alexion and TerumoBCT.

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