Proteinopathy in Neurodegenerative Disease

Event Time: Friday May 2, 2014 8:00 am to 12:00 pm
Topic(s): Aging, Dementia, Cognitive, and Behavioral Neurology, Subspecialty in Focus
Director(s): Carol Lippa , David Munoz MD
Description: The concept that abnormal aggregation of CNS proteins is a common link in all neurodegenerative diseases has emerged in recent years. Furthermore, spreading of pathology along neuronal connection pathways has been documented in at least some conditions, including Alzheimer’s and Parkinson’s disease. A prion-like mechanism of neuron to neuron transmission has been proposed. These developments have major implications for diagnosis and treatment. Abnormal protein identification is starting to be used for biomarkers to aid in diagnosis. Protein characterization is also an important consideration for evolving disease modifying treatment options. This activity will provide background information on how pathologic protein aggregates form and spread in the different classes of CNS degenerative diseases. It will also explore current and developing trends in diagnosis and treatment based on pathological proteins. This program is offered in partnership with the AAN Geriatric Neurology Section.
Completion Message: Participant should become familiar with how the different aberrant aggregates of specific proteins is leading to protein-based biomarkers for diagnosis of neurodegenerative disease and to the development of disease modifying treatments based on pathogenesis. They should be able to answer patient/caregiver questions regarding the potential infectivity of these diseases.
CME Credits: 4
Core Competencies:

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